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Jasper said: Brain shrinkage is not the only physiological affect of drinking alcohol. It causes a number of different diseases that affect the kidneys, liver, and yeah over time decreases your brain capacity. The whole lifestyle associated with drinking is destructive too. I was drinking for years and though I would notice things changing with my body, I didn't care too much about it. Thankfully quit drinking and decided to get up to date with my doctor visits and decided to get a colonoscopy. I had to have surgery on a small tumor, but if I never would've stopped drinking, I probably never would've went to the doctor in the first place and my condition would've been way worse.